Chapter 10 of 11

Talking to your GP

How to start the conversation, who can be prescribed GLP-1s, how the medications compare, and the questions people ask most.

Starting a conversation about weight or medication can feel daunting. You may worry about being judged or told to simply 'try harder'. Remember, seeking support is not a failure — it's a reflection of how complex weight regulation really is.

How to talk to your GP

It can help to frame the conversation around your health, not just your weight. It's often helpful to explain how long you've been struggling, what you've already tried, and how your weight is affecting your wellbeing. You can simply say:

I've been struggling with my weight and would like to discuss whether GLP-1 treatment might be appropriate for me.

You don't need to prove effort or justify yourself.

Am I eligible for treatment?

Eligibility depends mainly on your BMI and any weight-related health conditions. Use the quick check below to get a sense of where you stand — then, if it looks like a fit, you can move straight into Genwell's full eligibility check.

Your GP will usually want to know:

  • Your current weight and BMI
  • Any weight-related conditions (e.g. high blood pressure, type 2 diabetes, sleep apnoea)
  • Whether you are pregnant, breastfeeding or planning pregnancy
  • Your current medications

Who can be prescribed GLP-1 medications?

NHS

Starting with those who'll most benefit

  • BMI of 40 or more, and
  • Four weight-related conditions

MHRA approved use

A broader set of patients

  • BMI of 27+ with at least one weight-related condition, or
  • BMI of 30+ (living with obesity)

Private providers may prescribe 'off-label' to a wider group where evidence suggests benefit — this can include lower BMIs and conditions like PCOS or reflux disease.

Semaglutide or tirzepatide — which is right for me?

Semaglutide (Wegovy®)

  • Often more affordable
  • Effective for weight loss
  • Highest dose (7.4mg) licensed for obesity

Tirzepatide (Mounjaro®)

  • More effective at lower doses
  • Weight loss seen sooner
  • Often slightly better tolerated

Commonly asked questions

How long might I need to stay on treatment?

This varies from person to person. Obesity is a chronic condition needing long-term solutions, so ongoing treatment may help maintain results. Any decision to reduce, pause or continue should be taken with your clinician.

What happens if I stop?

Appetite signals gradually return and some weight regain is common — this reflects your body returning to its baseline biology, not failure. Building sustainable habits alongside treatment is key.

You do not need to know everything before asking for help. The most important thing is to start the conversation.